From the nucleus to mitochondria, we study the many layers of gene regulation.
We seek an integrative view of gene regulation to understand where, when and how genes are controlled.
We apply experimental and computational approaches that probe the many steps of gene expression, from transcription to translation.
Recent highlights
RNA flow analysis
How does RNA flow through the cell? From their synthesis, chromatin release, nuclear export, ribosome engagement, and eventual degradation, we quantified the lives of human transcripts genome-wide.
Regulators of mito-nuclear balance
Using a FACS-based CRISPR screen, we identified factors that coordinate mitochondrial and nuclear gene expression in order to produce dual-encoded oxidative phosphorylation complexes.
See what else we’ve been up to
We are a collaborative group of scientists with backgrounds in biology, physics, chemistry and computation.
We love our annual retreats
and can’t wait to have one again!
But most of the time, you can find us here.
Harvard Medical School
Blavatnik Insitute
New Research Building, 356
Boston, MA 02115